Azithromycin and potential risk of QT prolongation
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چکیده
n Rivaroxaban (Xarelto®) and reports of lack of efficacy in orthopaedic surgery indication ............................Page 8 Two recent research studies have strengthened the evidence regarding the potential risk of QT prolongation associated with the use of azithromycin. In the light of this latest data, healthcare professionals are advised to be aware of the risk of Torsades de Pointes and fatal arrhythmia when considering azithromycin as a treatment option for patients who are at risk for cardiovascular events. These patient groups include:
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Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes.
Macrolide antibiotics are known to have a different proarrhythmic potential in the presence of comparable QT prolongation in the surface ECG. Because the extent of QT prolongation has been used as a surrogate marker for cardiotoxicity, we aimed to study the different electrophysiological effects of the macrolide antibiotics erythromycin, clarithromycin, and azithromycin in a previously develope...
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